Make the punctuation of the next text appropriate for a title in English: Interactions Between Treatments for Depression, Anxiety, And Psychosis of the Costa Rican Social Security Administration (CCSS, for its Acronym in Spanish) and Medicinal Plants Preferred By The Costa Rican Population

Abstract

Since ancient times, medicinal plants have been a cornerstone in the treatment of various diseases. However, their concurrent use with conventional drugs can lead to adverse interactions, particularly in Costa Rica where the consumption of central nervous system medications is high. This study aims to identify potential interactions between the most popular medicinal plants in Costa Rica and drugs used to treat depression, anxiety, and psychosis, as well as the factors influencing their combined use. Plants with a high prevalence of use were selected and studies on their interactions with specific drugs were reviewed. Additionally, a literature review was conducted on the psychosocial and economic factors that may influence the consumption of these plants. 75% of the analyzed plants interact with the CYP3A4 enzyme, affecting drugs such as chlorpromazine, diazepam, and haloperidol. Interactions with P-glycoprotein were also identified, altering the absorption of drugs such as amitriptyline, clobazam, and clomipramine. In Latin America, factors such as low educational levels and economic costs significantly influence the use of medicinal plants. There is a high risk of drug interactions between medicinal plants and drugs for mental disorders in Costa Rica. It is essential for healthcare professionals to be aware of these interactions to ensure safe and effective care. More research and education on this topic are needed, both for professionals and the general population.